Halneuron®️
The non-opioid painkiller ​

Scientific Publications

List of Publications with Author(s) from WEX

Marcil J, Walczak JS, Guindon J, Ngoc AH, Lu S, Beaulieu P. Antinociceptive effects of tetrodotoxin (TTX) in rodents.

Br J Anaesth. 2006 Jun;96(6):761-8.

Hagen NA, Fisher KM, Lapointe B, du Souich P, Chary S, Moulin D, Sellers E, Ngoc AH; Canadian Tetrodotoxin Study Group. An open-label, multi-dose efficacy and safety study of intramuscular tetrodotoxin in patients with severe cancer-related pain.

J Pain Symptom Manage. 2007 Aug;34(2):171-82.

Guzmán A, Fernández de Henestrosa AR, Marín AP, Ho A, Borroto JI, Carasa I, Pritchard L. Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays.

Mutat Res. 2007 Dec 1;634(1-2):14-24.

Hagen NA, du Souich P, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Love R, Ngoc AH; Canadian Tetrodotoxin Study Group. Tetrodotoxin for moderate to severe cancer pain: a randomized, double blind, parallel design multicenter study.

J Pain Symptom Manage. 2008 Apr;35(4):420-9.

Hagen NA, Lapointe B, Ong-Lam M, Dubuc B, Walde D, Gagnon B, Love R, Goel R, Hawley P, Ngoc AH, du Souich P. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain.

Curr Oncol. 2011 Jun;18(3):e109-16.

Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia.

Mar Drugs. 2011 Dec;9(12):2717-28.

Hagen NA, Cantin L, Constant J, Haller T, Blaise G, Ong-Lam M, du Souich P, Korz W, Lapointe B. Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.

Pain Res Manag. 2017;2017:7212713.

Kavoosi M, O’Reilly TE, Kavoosi M, Chai P, Engel C, Korz W, Gallen CC, Lester RM. Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults.

Toxins (Basel). 2020 Aug 9;12(8):511.

Goldlust SA, Kavoosi M, Nezzer J, Kavoosi M, Korz W, Deck K. Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Dose Finding Trial.

Toxins (Basel). 2021 Mar 25;13(4):235.

List of Publications without Authors from WEX

González-Cano R, Ruiz-Cantero MC, Santos-Caballero M, Gómez-Navas C, Tejada MÁ, Nieto FR. Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?

Toxins. 2021 Jul 12;13(7):483.

Berde CB, Athiraman U, Yahalom B, Zurakowski D, Corfas G, Bognet C. Tetrodotoxin-bupivacaine-epinephrine combinations for prolonged local anesthesia.

Mar Drugs. 2011 Dec;9(12):2717-28.