Clinical Experience

Protocol	Location	Clinical Phase	Indication	Completion Status
MLP-001	China	Phase I	Healthy Volunteers	Completed
WEX-US-001	Canada / US	Phase I	PK study in Healthy Male Volunteers	Completed
WEX-001	Canada	Phase I	Healthy Volunteers	Completed
WEX-002	Canada	Phase I	Healthy Volunteers	Completed
WEX-015	Canada	Phase I	Healthy Volunteers	Completed
MLP-002	China	Phase IIa	Cancer Patients (Refractory pain)	Completed
WEX-003	Canada	Phase IIa	Cancer Patients (Refractory Pain)	Completed
WEX-008	Canada	Phase IIa	Cancer Patients (Refractory Pain)	Completed
WEX-014	Canada	Phase IIb	Cancer Patients (Refractory Pain)	Completed
WEX-014OL	Canada	Phase IIb	Cancer Patients (Refractory Pain)	Completed
TEC-006	Canada/Australia/New Zealand	Phase III	Cancer Patients (Refractory Pain)	Completed
TEC-006OL	Canada/Australia/New Zealand	Phase III	Cancer Patients (Refractory Pain)	Completed
TTX-CINP-201-PK	United States	Phase I	PK Study in Healthy Volunteers	Completed
TTX-CINP-201	United States	Phase II	Chemotherapy-Induced Neuropathic Pain	Completed
TTX-TQT-101	United States	Phase I	Cardiovascular Effect of Tetrodotoxin in Healthy Volunteers	Completed