TTX-CINP-201

Purpose

A Randomized, Double-Blind, Dose-Finding, Placebo Controlled, Phase II Multicenter Study of Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain.

The study was designed to determine the safety and effectiveness of various regimens of TTX in patients with neuropathic pain caused by chemotherapy. In addition, the study measured, time to the start and the duration of the pain relief, and whether TTX helps in improving quality of life parameters. The study determined that TTX was well tolerated, with promising early efficacy.